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Healthy Living >>> Men's Health Articles & News
How To Prevent Prostate CancerBy: DAVE WOYNAROWSKI, M.D.The World's Top Anti-Aging Specialist In order to get the most out of this article, you need to have read the "Male Menopause" article first. Let's review just a bit about the topic of Male Menopause, also called Andropause, and testosterone metabolism. Overall testosterone is a good hormone to have around if you are a guy. It promotes mental sharpness well being, muscle retention and growth, bone strength, sex drive, fat burning, heart health and lower blood sugars. Again this is a short list. Please try to divorce yourself from the image of the muscle laden vein popping 'roid raged body builder who is taking 10X more hormone than is physiologic (normal) here. Also understand that as an anti-aging doctor, my version of normal is what you would get if you took a typical 32 year old man who was in the 75% range of his group as far as testosterone levels is concerned. Whether you are 40, 60 or 80 that is about the range I am shooting for. Ok so normal amounts of testosterone is good. The natural breakdown products of testosterone are DHT via an enzyme found primarily in the skin and prostate called 5 alpha reductase. From DHT we go to estrogen via an enzyme that is plentiful in the fat called Aromatase. While it is normal for men to have some DHT and Estrogen around, it is not normal for these breakdown products or metabolites to be the dominant hormones in terms of effect or number. The aging process in men generally leads to decreased signals from the brain to make testosterone, decreased production of testosterone from the testis, or both. Because of other complex hormonal interplays, the aging man tends to get fatter especially around the middle. Lower levels of Growth hormone are mainly responsible for that along with life style and metabolic changes which again may be hormonally driven. AS fat accumulates and less testosterone is made, the activity of Aromatase goes up leading to more estrogen. Additionally at least in some men 5 alpha reductase activity also seems to go up which leads to more DHT which in turn feed the estrogen pipeline. In the past Prostate cancer was thought to be only driven by testosterone. But as usual when people looked more closely at the situation new understanding was gained. One very fascinating finding was that men with the highest levels of testosterone seemed to have the least prostate cancer. Again this flies in the face of what was previously taught. Early treatments for prostate cancer included removal of the testis and putting men on estrogens! Recently it was found that men taking drugs to shrink their prostate actually had a significant decrease I the numbers of prostate cancer. This led scientists to look at DHT as the culprit. But again this is probably too simplistic. Less DHT leads to less estrogen which is I think where the real answer lies. Again if you block the formation of DHT you get, less hair loss, less acne and skin problems and ultimately less estrogen and Prostate cancer! I will never forget a round table discussion I sat in on where 2 experts on prostate cancer were debating the question of using testosterone in men with prostate cancer. One doctor said, "That is absolutely contraindicated and would be malpractice!"
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